Gene targets for critical-mineral bioprocessing

Direction

Prioritize genes and modules that improve tolerance or recovery-relevant metabolism for critical minerals.

Why It Is High Value

The observatory already has metal-specific candidate families, pangenome conservation, updated annotations, and structural resources. The missing step is a ranked, evidence-graded engineering candidate list.

Candidate Evidence Stack

  • Metal-specific fitness phenotype.
  • Conserved family or module context.
  • Annotation or reannotation support.
  • Structure/topology consistent with metal handling.
  • Minimal pleiotropic cost.

First Hypotheses