Structures support metal-binding or transport roles
Top metal-specific candidates have predicted structures or topology consistent with metal binding, transport, or regulation.
Opportunity Hooks
Rare-Earth RB-TnSeq Design
Design the first rare-earth fitness experiment by ranking candidate genes from cross-metal specificity, conservation, annotation, and structure evidence.
Dark Gene Structure Prioritization
Prioritize dark gene families for mechanistic review by joining fitness, cofitness, annotation novelty, and AlphaFold structure signals.
Structures support metal-binding or transport roles
Hypothesis
Top metal-specific candidates such as UCP030820, YebC, and DUF1043/YhcB have structural features consistent with metal handling, membrane transport, or stress-specific regulation.
Testable With
AlphaFold, UniProt, topology prediction, conserved residues, and family-level annotation.
Expected Output
A ranked candidate list with structural support, ambiguity, and experimental follow-up.