Cross-cohort metabolite ecotypes require batch correction
Absolute-intensity metabolite ecotypes are dominated by cohort batch effects unless corrected before clustering.
Opportunity Hooks
Cross-cohort metabolite ecotypes require batch correction
Hypothesis
Pooled absolute-intensity metabolomics clusters separate by cohort before biology unless batch correction is applied.
Testable With
Cross-cohort metabolomics, PCA or clustering diagnostics, cohort labels, and corrected versus uncorrected comparisons.
Agent Rule
Do not treat taxonomy-relative and metabolite-absolute feature spaces as equally portable across cohorts.