Opportunity Hooks

Metal-AMR Site Co-Selection Analysis

Test whether metal contamination at BER-relevant sites co-selects antibiotic resistance mechanisms using metal fitness, AMR profiles, and environmental metadata.

impact high readiness high

Open Tensions

unresolved

Metal-AMR co-selection readiness

BERIL has the pieces to test metal-AMR co-selection, but the current evidence is a strong opportunity rather than a resolved result.

Metal contamination co-selects AMR mechanisms

Hypothesis

Metal-contaminated environments select for AMR mechanisms directly or indirectly through shared transport, stress response, mobile elements, or ecological filtering.

Testable With

AMR annotations, metal tolerance scores, metal type diversity, prophage/mobile-element burden, soil or site geochemistry, ENIGMA site context, and phylogenetic controls.

Failure Mode

Taxonomic composition, mobile-element burden, co-contaminating metals, spatial sampling, or project effects explain the signal. The test must include nulls, stratification, and sensitivity analyses.

Source Projects

Environmental Resistome at Pangenome Scale Pan-Bacterial Metal Fitness Atlas SSO Subsurface Community Ecology — Spatial Structure, Functional Gradients, and Hydrogeological Drivers Antibiotic Resistance Hotspots in Microbial Pangenomes Metal Resistance Ecology: Phylogenetic Conservation vs. Environmental Selection Prophage-AMR Co-mobilization Atlas Soil Metal Concentrations Drive Functional Gene Shifts in the Environmental Microbiome

Collections

Pangenome Collection ENIGMA CORAL Fitness Browser

Related Atlas Pages

Review Routes

Paramvir S. Dehal Paramvir S. Dehal Adam Deutschbauer Adam Arkin William J. Riehl Metal Resistance Ecology: Phylogenetic Conservation vs. Environmental Selection Justin Reese Claude (AI co-scientist